Academy Award winner Jodie Foster is reportedly in talks for a key role in FX's adaptation of Y: The Last Man.

The cable network ordered a pilot in April based on the acclaimed DC/Vertigo comic series by Brian K. Vaughan and Pia Guerra, which follows Yorick Brown, an amateur escape artist who, with his pet Capuchin monkey Ampersand, is the last survivor of a mysterious plague that killed every other male mammal on Earth. The two set off on a globe-spanning journey to reunite with Yorick’s girlfriend, discover what wiped out the world’s Y chromosomes and find out why they survived.

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According to That Hashtag Show, Foster is in talks to play Yorick's mother Jennifer Brown, a congresswoman from Ohio who, after the plague, become secretary of the interior.

A celebrated actor, director and producer, Foster won Oscars for her performances in The Accused and The Silence of the Lambs, and was also nominated for Taxi Driver and Nell. In recent years she's taken fewer acting roles, choosing instead to focus on directing; she appeared most recently in 2013's Elysium and this year's Hotel Artemis, and as narrator of an episode of Makers: Women Who Make America.

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New Line Cinema acquired the film rights to Y: The Last Man in 2007, with D.J. Caruso “loosely attached” until he exited the project following a disagreement about format; he envisioned a trilogy, while the studio wanted a single film. The adaptation was revived by New Line in 2012, when it was considered a priority for the studio, but the film rights reverted to Vaughan and Guerra in 2014. The following year, FX announced plans to develop Y for television, with Green hired as showrunner. However, he was also committed to oversee Starz’s American Gods with Bryan Fuller, at least until the duo exited the project in November 2017 following Season 1. With Green available once again, FX CEO John Landgraf expressed confidence earlier this year that there would be movement on the project.

Melina Matsoukas (Insecure) will direct the pilot, written by Michael Green (American Gods, Blade Runner 2049), who will serve as showrunner with Aida Mashaka Croal (Luke Cage, Turn).